cellular lipid metabolism :: frontotemporal dementia progranulin & frontotemporal dementia recently, as part of the consortium for frontotemporal dementia (ftd) research (cfr), we began to study the basic biology of ftd, a devastating neurological disease that is the second most common cause of dementia in patients under age 65. viagra yahoo email virus Ftd is characterized by degeneration in both the frontal and temporal lobes, and there are no effective therapies. The cfr is ucsf-based group of about a dozen laboratories (basic science and clinical) that are dedicated to finding therapies for ftd within 10 years through systematic collaboration. online cialis
Our laboratory has a small group dedicated to helping fulfill the mission of the cfr. Our work focuses on the biology of progranulin, one of the major genes in which mutations have been linked to ftd. cialis levitra viagra
Progranulin is a secreted growth factor that has been implicated in development, wound repair, and inflammation. Our lab is creating mouse models of ftd, and we are using them to explore the function of progranulin in microglia and neurons. We are also generating patient-specific induced pluripotent stem (ips) cell lines to explore ftd mechanisms and to test therapies. Tdp43 is a protein that has been found in pathological aggregates in neurons of progranulin-deficient patients. Using yeast model systems, we are investigating the mechanism of tdp43 aggregation and toxicity and searching for potential therapies. : : : gladstone institutes : : : university of california, san francisco : : : lab intranet : : :. About us help contact us login create account text size bigger smaller normal current size: 100% about dementia > frontotemporal dementia: introduction symptoms of frontotemporal dementia the two main symptoms of frontotemporal dementia are changes in personality and loss of the ability to express and understand language. generic cialis
Unlike alzheimer's disease and lewy body dementia, ftd does not affect an individual's memory. viagra salesman jamie ready Changes in personality ftd affects the front, right side of the brain, which controls our judgment, personality, and ability to manage complex tasks. average cost of viagra Individuals with this form of dementia might look like they are "acting up" because they may start behaving oddly or inappropriately in public places or around strangers. online cialis sales
Social skills like tact and empathy may be lost. average cost of viagra They may lose interest in everything, or they may suddenly need to be active all the time. mg for viagra They often lose the ability to make informed and safe decisions about tasks, such as managing finances or driving in the car. cialis online shop
When the behavioral problems are the most obvious, this form of dement. cialis for sale
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